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Tissue Transglutaminase Antibody

The Tissue Transglutaminase testing is used to help diagnose the presence of Coeliac Disease.  Tissue transglutaminase is an IgA enzyme that fixes damage in the body.  This enzyme is usually present in patients with Coeliac disease.  The antibodies that attack these enzymes are called anti-tissue Transglutaminase antibodies.  A blood test that indicates increased levels of these antibodies can help a practitioner to determine the presence of Coeliac Disease.

Test results may vary depending on health history, gender and age.  The higher levels of Tissue Transglutaminase  antibodies in your blood, the increase likelihood of a related inflammatory disorder.  In younger children, tissue transglutaminase antibodies may not appear in increased levels in children with Coeliac disease.  This may be due to lack of established immunity.

This test can be utilized in patients with increased risk of disease (previous diagnosis with associated disorder, family history, positive for HLA DQ2 and/or DQ8).  Coeliac disease is an autoimmune disorder of the small bowel characterized by mucosal inflammation, villous atrophy and crypt hyperplasia which occurs upon exposure to dietary gluten.  Gluten is a protein found in foods such as wheat, barley, rye and oats.  Coeliac disease usually presents with gastrointestinal symptoms such as diarrhea, malabsorption, or weight loss. 


Specimen Requirements

One blood sample is required for completion of test.  Take a referral along to the nearest Australian Clinical Labs collection centre.  Find your nearest collection centre by going online at www.clinicallabs.com.au or contacting us on 1300 554 480.


Turnaround Time

The standard turnaround time for this test is 5 – 7 working days from the date the patient’s specimen/s are received by our laboratory.


Test Results

Patient results are delivered via electronic download unless requested otherwise. Results can also be issued via hardcopy, fax or web based e-viewer.


Technical Support

All Australian Clinical Labs Functional Pathology tests are accompanied by an Interpretive Guide to assist practitioners in their clinical understanding and patient management for each result. Australian Clinical Labs Functional Pathology also has experienced full time Technical Advisors available for practitioners to discuss appropriate test selection, interpretation of test results, individual cases and other technical matters. Please call 1300 55 44 80 between the hours of 9:00am and 5:00pm  AEST or email csfp@AustralianClinicalLabs.com.au