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2 & 16 Oestrogen Metabolites

The test monitors oestrogen metabolism in men and women. The test helps to determine patients at high risk of hormone imbalance.  High levels of circulating oestrogens are proliferative and potentially dangerous; it is important that they are broken down efficiently and effectively removed from the body.

Oestrogens are metabolised in two ways: the first pathway (2-hydroxyoestrone) is protective whilst the second pathway (16-hydroxyoestrone) is more potent.  This test identifies which is the dominant pathway (2 or 16) for oestrogen metabolism.  The aim is to ensure that the ratio between the 2:16 pathways is maintained at the ideal of 2.0.

A low ratio (reduced 2 hydroxyl metabolite production), indicates a state of oestrogen excess which may be a contributing factor to oestrogen-dependant cancers (such as  breast, head/neck and prostate cancer).  A high ratio indicates an oestrogen deficient state which may indicate an increased risk of osteoporosis.


Test Kit

Once the practitioner has given the patient their request form the patient can order their test kit online at Clinicallabs.com.au or by calling Australian Clinical Labs Functional Pathology customer service on 1300 55 44 80 between the hours of 9:00am and 5:00pm AEST. The test kit contains full instructions.


Specimen Requirements

One urine specimen collected from the first morning void (the first urine after waking in the morning).  The test kit provided contains everything required to complete the test.


Turnaround Time

The standard turnaround time for this test is 10 – 14 working days from the date the patient’s specimen/s are received by our laboratory.


Test Results

Patient results are delivered via electronic download unless requested otherwise. Results can also be issued via hardcopy, fax or web based e-viewer.


Technical Support

 All Australian Clinical Labs Functional Pathology tests are accompanied by an Interpretive Guide to assist practitioners in their clinical understanding and patient management for each result. Australian Clinical Labs Functional Pathology also has experienced full time Technical Advisors available for practitioners to discuss appropriate test selection, interpretation of test results, individual cases and other technical matters. Please call 1300 55 44 80 between the hours of 9:00am and 5:00pm  AEST or email csfp@AustralianClinicalLabs.com.au