Helicobacter Pylori Breath Testing

Helicobacter pylori
C14 Urea Breath Test

  • Purpose of this test

    This test is used for detecting the presence of bacteria called Helicobacter pylori, which can cause stomach inflammation. It may also be used to check that the bacteria have been eradicated after treatment. The capsule used in this test results in exposure to a very small amount of radiation, similar to what we receive from the general environment in a day. If you are pregnant, could be pregnant, are breastfeeding, or if the test is for a child under 12 years old, an alternative test (H. pylori stool antigen) is recommended. Please discuss this with your doctor. Patients may drink one glass of water every hour after the test to hasten the excretion of the radioisotope.

  • Preparation for the test

    You are to fast for a minimum of 6 hours prior to the test (no food or drink, including water). No smoking for a minimum of 2 hours before the test. The medications listed below should NOT be taken prior to the test. Consult your doctor before stopping any medications.

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    Exclusion PeriodType of MedicationGeneric NameTrade Names
    Four WeeksAntibioticsAmoxycillin (Penicillins)Abbocillin, Alphamox, Amoxil, Augmentin, Bgramin, Cilamox, Clamoxyl, Clavulin, Clavycillin, Curam, Fisamox, Maxamox, Moxiclav, Ranmoxy, Yomax
    Ampicillin (Penicillins)Ampicyn, Austrapen, Ibimicyn
    Azithromycin (Macrolides)Azith, Zedd, Zithromax, Zitrocin
    Cefaclor (Cephalosporins)Ceclor, Karlor, Keflor, Ozcef
    CephalexinCephatrust, Cilex, Keflex, Ialex, Ibilex, Rancef
    Ciprofloxacin (Quinolones)C-Flox, Cifran, Ciprol, Ciproxin, Proquin
    Clarithromycin (Macrolides)Clarac, Clarihexal, Clarithro, Kalixocin, Klacid
    Erythromycin (Macrolides)EES, E-Mycin, Eryc, Erythrocin
    MetronidazoleFlagyl, Metronide, Metrogyl, Simplotan
    RifaximinXifaxan
    Roxithromycin (Macrolides)Biaxsig, Roxar, Roximycin, Rulide
    TetracyclinesAkamin, Doryx, Doxsig, Doxy, Doxycycline, Doxyhexal, Doxylin, Frakas, Minocycline, Minomycin, Tetracycline, Vibra-tabs
    TrindaxoleFasigyn
    30 Days Prior to TestOther Anti-infectivesBismuthDenol, Helldac
    14 Days Prior to TestCytoprotectivesSucralfateCarafate, Ulcyte
    7 Days Prior to TestProton Pump InhibitorsLansoprazoleLanzopran, Zopral, Zoton
    RabeprazoleParzol, Pariet, Prabez, Rabzole, Razit
    OmeprazoleAcimax, Losec, Meprazol, Maxor, Omepral, Omepro-GA, Pemzo, Ozmep, Probitor
    EsomeprazoleNexium
    PantoprazoleGastenz, Ozpan, Panthron, Panto, Pantofast, Pantoloc, Pantomac, Pantozol, Salpraz, Somac, Sozol, Suvacid, Torzole
    During Fasting and During TestAntacidsALU-TAB, Andrews Tums Antacid, DeWitts Antacid Powder, ENO, Gastrogel, Gaviscon, Mylanta, Rennie, Titralac
    During Fasting and During TestH2 AntagonistsCimetidineMagicul, Tagamet
    RanitidineAusran, Rani 2, Ranital, Ranoxyl, Ulcaid, Ultac,
    Zantac
    FamotidineAusfam, Famohexal, Pamacid, Pepcidine, Pepzan
    NizatidineNizac, Tacidine, Tazac
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    The above is not an exhaustive list. If you are unsure about the classification of a medication, please consult your doctor or pharmacist.

    Please note: While it is preferable that you have FULLY complied with the testing requirements, testing can be conducted if, for example, certain medications cannot be stopped as advised by your doctor. In these cases, ensure this is clearly documented in the questionnaire you will complete before your test.

  • Collection procedure

    1. You will be required to swallow a capsule (do not chew) with approximately 30mL of water.
      Do not handle the capsule directly.
      (PYtest® Capsule AST R 67146 containing 37 kBq 14C-urea)
    2. Three minutes later, you will be required to swallow a further 30mL of water.
    3. You will then wait for 7 minutes and be instructed to take a deep breath, hold for approximately 10 seconds, and blow into a balloon until it is firm.
  • Answers to commonly asked questions

    • It is OK to have brushed your teeth before testing.
    • It is OK to have used an asthma puffer.
    • It is OK to have had a sip (5-10 mL) of water in the last 6 hours, but no more than that.
    • Taking vitamins or herbal supplements in the last 4 weeks will NOT interfere with the test.

    Important: Testing for cure or eradication of H. pylori should only be performed at least 4 weeks after completion of antibiotic therapy, not sooner.

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