Australian Clinical Labs Pathology can also test thyroid antibodies – thyroglobulin and thyroid peroxidase. This can be added as an optional extra to the Thyroid Hormone Profile to provide a comprehensive assessment of thyroid function.
Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against thyroglobulin. Thyroglobulin-specific antibodies help in the diagnosis of these diseases, but they may also be present in apparently healthy euthyroid individuals.
It is a frequent epitope of autoantibodies in autoimmune thyroid disease so the antibody titre can be used to assess disease activity in patients who have developed such antibodies. An epitope is the part of antigen that reacts with an antibody of a T cell receptor.
The presence of auto-antibodies against thyroglobulin, indicates possible inflammation of the thyroid gland (Hashimoto’s thyroiditis). High levels are found in Hashimoto’s thyroiditis (85%), thyroid carcinoma (45%) and Grave’s disease (30%).
Low levels of antibodies are found in 10% of normal patients, many autoimmune conditions (including pernicious anaemia and Systemic Lupus Erythematosus) and some chromosomal disorders, such as Turner’s syndrome and Down’s syndrome.
Thyroid Peroxidase Antibodies/TPO Ab
The presence of thyroid peroxidase antibodies is also indicative for autoimmune thyroid disorders. The enzyme thyroid peroxidase (TPO) appears to be the particular component of the microsomes that directly target the auto-antibodies that cause illness.
They may be positive in Hashimoto’s thyroiditis, idiopathic myxoedema and Grave’s disease. Non-immune thyroid disorders show no greater incidence than normal.
A blood specimen is required, which can be taken at any time of the day. Fasting is not required.
Once the practitioner has given the patient their request form, the patient takes it to their nearest Australian Clinical Labs collection centre. If you are unsure of your nearest collection centre head to location on our website or call us on 1300 554 480 between 9.00am and 5.00pm Monday to Friday for details.
Turnaround time is usually 7-10 working days.
Patients does not need to fast or make any special preparation before having blood collected.
Patient results are delivered via electronic download unless requested otherwise. Results can also be issued via hardcopy, fax or web based e-viewer.
All Australian Clinical Labs Functional Pathology tests are accompanied by an Interpretive Guide to assist practitioners in their clinical understanding and patient management for each result. Australian Clinical Labs Functional Pathology also has experienced full time Technical Advisors available for practitioners to discuss appropriate test selection, interpretation of test results, individual cases and other technical matters. Please call 1300 55 44 80 between the hours of 9:00am and 5:00pm AEST or email csfp@AustralianClinicalLabs.com.au