Somatic Mutation | Solid Tissue Molecular Profiling in Thyroid Cancer
Thyroid Cancer Test Panel (DNA)
In anaplastic thyroid cancer (ATC), BRAF p.V600E mutation occurs in ~40% of patients with papillary thyroid carcinoma (PTC) and is associated with a more aggressive disease1,2.
Genes sequenced in this panel include:
BRAF | KRAS |
NRAS | RET |
Test cost: No Medicare rebate available.
Medullary Thyroid Cancer (MTC) Panel
Medullary thyroid cancer (MTC) is associated with oncogenic mutations in RET (40-60%) that can be targeted by therapeutic treatments3.
Genes sequenced in this panel include:
Oncogenic mutations in RET |
Test cost: No Medicare rebate available.
When to Order: At diagnosis or on therapy for treatment selection.
How to Order: Fill out our Somatic Mutation testing request form.
Turnaround Time: 5-7 business days from the sample receipt date.
Specimen Required: Fresh formalin-fixed paraffin-embedded (FFPE) of 5-10 μm thickness from the tumour tissue.
Test Cost: Thyroid Cancer Test Panel (DNA): No Medicare rebate available.
Medullary Thyroid Cancer (MTC) Panel: No Medicare rebate available.
References
1. Cohen Y et al., (2004) Clin Cancer Res 10(8):2761–2765.
2. Xing M et al., (2005) J Clin Endocrinol Metab 90(12):6373–6379.
3. Malone E et al., Genome Medicine (2020). Molecular profiling for precision cancer therapies 12:8.
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The content on our Molecular Cancer Services page is written by Associate Professor Mirette Saad, National Director of Molecular Genetics at Australian Clinical Labs.
Assoc. Prof. Mirette SaadMBBS (Hons), MD, MAACB, FRCPA, PhD |
Associate Professor Mirette Saad is a Consultant Chemical Pathologist and the National Director of Molecular Genetics at Australian Clinical Labs. She has a Fellowship with honours in Chemical and Molecular Pathology, with Microbiology sub-speciality, from Suez Canal University, Egypt. A/P Saad received her NHMRC sponsored PhD degree in Cancer Genetics from Melbourne University and Peter MacCallum Cancer Institute. Along with her teaching and research roles, A/P Saad is a registered medical practitioner with AHPRA, a Chemical Pathology Fellow (FRCPA) at the Royal College of Pathologists of Australasia and a Member of the Australasian Association of Clinical Biochemists (MAACB). She is a Chair of the RCPA Chemical Pathology Advisory Committee, Member of the RCPA Genetic Advisory Committee, AACB and a Chair of the Precision Medicine Services at Australian Clinical Labs. At Clinical Labs, A/Prof Mirette Saad leads the Molecular Genetic testing for non-invasive prenatal testing (NIPT), antenatal screening, personalised drug therapy and cancer.